179 Responses

  1. 41 Procarbazine hydrochloride Azoospermia Supported in mice 42 , unclear for humans all trials have used combination therapy 43 Triptorelin pamoate Testicular atrophy Supported in humans 44 Vinblastine sulfate Azoospermia Supported in rats 45 and in vitro for humans 46 Vinorelbine tartrate Damage to spermatozoa No data published in animals or humans Thalidomide Orchitis Supported in rabbits 47 , no data for humans Anti-Parkinson agent Pramipexole dihydrochloride Epididymitis, orchitis No data published for animals or humans Antipsychotic agent Quetiapine fumarate Orchitis infrequent No data published for animals or humans Anti-rejection drug Everolimus Azoospermia or oligozoospermia 1 of patients No data published for animals or humans Antiviral agent Delavirdine mesylate Hematospermia, epididymitis No data published for animals or humans Ganciclovir ganciclovir sodium Testicular hypotrophy, aspermatogenesis dose-dependent Supported in rats 48 , no data in humans Valganciclovir Inhibition of spermatogenesis No specific data published, but is expected to result in the same effects as ganciclovir Cardiovascular agent Bosentan Decreased sperm count No data published for animals or humans Hormones, hormone substitutes and hormone antagonists Clomiphene citrate Testicular tumors Supported in humans 49 , but used to treat infertility improves sperm parameters; 50 Danazol Decreased spermatogenesis, abnormalities in semen volume, viscosity, sperm count, and motility Supported in humans 51 Dutasteride Decreased sperm count, semen volume, and sperm motility Supported in humans 52 Finasteride Decreased ejaculate volume and total sperm per ejaculation reversible Supported in humans 52 Flutamide Interference with testosterone, decreased sperm count Supported in mice 53 , supported in combination with other agents in humans 54 Histrelin acetate Testicular atrophy Supported in rats 55 and rhesus monkeys 56 , no data for humans Leuprolide acetate Suppressed testicular steroidogenesis, testicular atrophy Supported in humans 57 , also may be useful for protecting restoring fertility following toxic insults 58,59 Methyltestosterone Oligozoospermia, suppressed spermatogenesis Supported in dogs 60 and rats 61 , no data for humans Nandrolone decanoate Inhibition of testicular function, testicular atrophy and oligozoospermia, epididymitis Supported in humans 62 Nilutamide Testicular atrophy No data published for animals or humans Oxandrolone Suppressed spermatogenesis, inhibition of testicular function, testicular atrophy, oligozoospermia, epididymitis Supported in rats 63 and in a human case report 64 Oxymetholone Inhibition of testicular function, testicular atrophy, oligospermia, decreased seminal volume, epididymitis Supported in mice 65 and rats 66 , no data for humans Testosterone testosterone cypionate testosterone enanthate testosterone undecanoate Suppressed spermatogenesis oligozoospermia, testosterone undecanoate may also cause spermatocele formation Supported in humans 67 69 , but dose-dependent and variable results Immunosuppressant Sirolimus Azoospermia reversible Supported in humans 70 PDE5 inhibitor Tadalafil Decreased sperm concentration Refuted in humans 71,72 Peripheral nervous system agent Cevimeline hydrochloride Epididymitis No data published for animals or humans Radioactive compound Sodium iodide I 131 Impairment of testicular function transient infertility Supported in humans 73. where to get nolvadex

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